ABSTRACT
Colchicine is a drug widely used for the management of many disorders, such as acute gout and Behçet’s disease. It is also prescribed for the treatment of pericarditis, atrial fibrillation coronary artery diseases, and secondary amyloidosis. In case this drug is used at the early stages of coronavirus infection, its anti-inflammatory properties may reduce the severe inflammatory reactions related to a cytokine storm by affecting the inflammasome. The purpose of the present study was to determine the toxicity of Colchicine on testis in rats from different age groups for 10 days. A total of 27 male Wistar rats were divided into three groups. The rats in group I (control group) were administered distilled water by oral gavage. Group II consisted of young rats (5-6 months old) who orally received Colchicine 3 mg/kg body weight. Group III entailed rats of 14-16 months who were orally administered colchicine 3 mg/kg body weight. The testis of the treated groups was dissected and examined for histological changes and morphometrical analysis. The obtained results indicated that high doses of Colchicine (3 mg/kg body weight) could induce tissue damage to the testis, including degeneration and necrosis of both Sertoli and Leydig cells with irregular divisions of germinal epithelium, even when it was used for short periods (10 days). In the elderly treated rats, there were severe tissue damages, including degeneration and necrosis of germinal epithelium with irregular divisions of germ cells, necrosis of Sertoli and Leydig cells with sloughing of germinal epithelium toward the lumen of the tubule. Therefore, there is a need to conduct more studies to investigate the side effect of Colchicine as it is excessively used in the management of coronavirus.
ABSTRACT
Covid 19 is pandemic all over the world. It has been first detected in China in 2019 among people working in animal market. It is caused by corona virus which has close relation to SARS which was first detected in 2007. Coronavirus can produce symptoms which is varied from simple common cold like disease to severe respiratory disease including respiratory distress condition. Most of the postmortem lungs showed histological picture of diffuse alveolar damage, pneumonia, thromboembolism of small sized pulmonary arteries and pulmonary embolism.But those elderly people or those with chronic illnesses they showed more serious and life-threatening symptoms like difficult breathing, dyspnea, chest pain or even loss of speech and movement. This review study focused on the histological findings in the autopsy of lungs in patients died from coronavirus. The present study concluded that the principal cause of death in covid 19 patients is the acute respiratory distress syndrome which showed a histological picture of diffuse alveolar damage, microvascular damage and pulmonary thromboembolism.